Gastric mucosal barrier: barrier to hydrogen ions imparted by gastric surfactant in vitro.

Gastric surfactant and the hydrophobic mucosal barrier.

Is the apparent hyposecretion of acid by patients with gastric ulcer a consequence of a broken barrier to diffusion of hydrogen ions into the gastric mucosa?

The recent papers by Johnson, Love, Rogers, and Wyatt (1964) and Langman, Hansky, Drury, and Jones (1964) clearly distinguish between ulcers of the oxyntic gland area of the stomach on one hand and ulcers of the pyloric gland area and of the duodenum on the other. The former are true 'gastric' ulcers. The fluid recovered from the stomachs of patients with gastric ulcers is large in volume but l...

The effect of bile on the gastric mucosal barrier in the presence and after blockade of normal gastric acidity.

Induced physiologic changes in the gastric mucosa was investigated both in the presence of normal gastric acidity and after parietal cell vagotomy (PCV), in dogs. Cholecystogastrostomy and common bile duct ligation was performed in eleven and PCV was added to this procedure in five dogs. During histopathological examination, 70 days after the procedure, both groups proved to have superficial ga...

Mucosal acidification increases hydrogen sulfide release through up-regulating gene and protein expressions of cystathionine gamma-lyase in the rat gastric mucosa

Objective(s): This study was performed to investigate the effects of mucosal acidification on mRNA expression and protein synthesis of cystathionine gamma lyase (CSE), cystathionine beta synthase (CBS), and mucosal release of H2S in gastric mucosa in rats. Materials and Methods:Thirty-two rats were randomly assigned into 4 groups (8 in each), including: the control group, HCl (10 mM) treated g...

Effect of 16,16-dimethyl prostaglandin E2 on the gastric mucosal barrier.

16,16-dimethyl prostaglandin E2 (16DM) can protect the gastric mucosa from injury and yet apparently damages the gastric mucosal barrier. The effect on the gastric mucosal barrier of 16DM (26.2 micromol/l), a dose 50 times the ED50 for inhibition of acid secretion, was investigated in Heidenhain pouches in four dogs by measuring plasma shedding from the pouches after the topical application of ...